Nueva semana, nuevo Coloquio en IFIS. Ana Zúñiga Sepúlveda, perteneciente al Centre de Biologie Structurale, Montpellier, Francia, presenta “Precision Logic Programming in Bacteria: A New Frontier in Healthcare” este miércoles 27 de noviembre a las 11:00 AM en la Sala 208 del Instituto de Física PUCV.
Te dejamos el abstract del coloquio:
Synthetic biology is unlocking new possibilities for addressing global challenges by engineering biological systems with innovative functionalities. A cornerstone of these advancements is the ability to detect and process multiple signals, essential for applications across healthcare and biotechnology. Among the many approaches, recombinase-based logic circuits stand out. These circuits leverage site-specific recombinases to selectively invert or excise DNA segments, allowing precise control over genetic elements based on input order. Recombinase logic offers key advantages such as single-layer architecture, memory retention, low metabolic demands, and cross-species portability.
Our work introduces a systematic framework for developing history-dependent, multicellular programs, employing standardized DNA scaffolds where genes activate transcriptionally according to sequential inputs. These modular computing systems can be adapted for diverse species and respond to various chemical or physical stimuli. Currently, we are harnessing these programmable systems to orchestrate the iterative assembly of synthetic biological structures, with transformative implications for healthcare applications.
